Hi'CT: a pixel sensor-based device for ion tomography

Abstract Carbon ions, commonly referred to as particle therapy, have become increasingly popular in the last decade. Accurately predicting range of ions tissues is important for precise delivery doses heavy-ion radiotherapy. Range uncertainty currently largest contributor dose normal tissues, leading use safety margins treatment planning. One potential method direct relative stopping measurement (RSP) with ions. Heavy-ion CT (Hi′CT), a compact segmented full digital tomography detector using monolithic active pixel sensors, was designed and evaluated 430 MeV/u high-energy carbon ion pencil beam Geant4. The position individual track can be recorded reconstructed 30 μm × small pitch size. Two types customized image reconstruction algorithms were developed, their performances three different modules CATPHAN 600-series phantoms. RSP accuracy tracking algorithm materials CTP404 module less than 1%. In terms spatial resolution, could achieve 20% modulation transfer function normalization value CTP528 imaging results at 5 lp/cm, which significantly better that fast (3 lp/cm). density resolution obtained CTP515 approximately 10.5%. conclusion, Hi'CT system designed, its nominal performance simulation. quality provide feasibility scanning most parts an adult body or pediatric patient, particularly head neck tumor treatment.